Formula X-22
From superman.nu: Supermanica
An unknown alien chemical stored within Superman's Fortress of Solitude that exists in gaseous form and causes normal human beings to develop extreme criminal tendencies. In August 1966, Perry White upset a bottle containing the chemical, which radically altered the personalities of both himself and James Gordon, leading them to become Anti-Superman and Anti-Batman. (WF No. 159, August 1966: "The Cape and Cowl Crooks!")
